Affective symptoms and vascular factors are more prevalent in non-amnestic 
than amnestic Mild Cognitive Impairment (MCI) 
 
   Lead Investigator:    Paul Rosenberg
   Institution      :    Johns Hopkins
   E-Mail           :    prosenb9@jhmi.edu
   Proposal ID      :    32


   Publications:


1  Rosenberg PB, Lyketsos CG
   A New Concept: The Concept of Mild Behavioral Impairment (MBI)
   2010   Abstract  Emotions Et Cognition Dans Les Maladies Neurologiques, Marseille France , 

   ACCEPTED



2  Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakos JM, Lyketsos CG
   Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
   Journal Article  Int J Geriatr Psychiatry,26:364-372,2011,PMC3204866

   PUBLISHED





   Proposal Description:
   HYPOTHESES, SPECIFIC AIMS, AND DATA ANALYSES  Hypotheses 1 and 2  Participants with nMCI will have a higher prevalence and greater severity of 1) affective symptoms (depression, apathy, anxiety and irritability) and 2 ) vascular conditions than participants with aMCI and cognitively normal controls.  Specific Aims 1 and 2  1) To compare scores on Neuropsychiatric Inventory (NPI) affective domains and Geriatric Depression Scale (GDS) and 2) To compare the prevalence of vascular conditions (coronary artery disease, cerebrovascular disease, atrial fibrillation, diabetes, hypercholesterolemia, and hypertension) between participants with nMCI, aMCI,and cognitively normal controls.